Publications in last five years

2025

Goh, K.Y., Lee, W.X., Gou, Q., Choy, S.M., Ong, S.C., Gopal Krishnan, P.D., Wang, H., Turqueza, L.R.R., Tan, Q.H., Chua, K., Li, S., Nishiyama, J., Harmston, N., Tang, H.W. Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles. Nat Commun (2025). (Accepted)

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Lee, W. X., Goh, K. Y., Choy, S. M., & Tang, H. W. (2025). DEAF1 - a transcriptional brake on muscle autophagy. Autophagy, 1–2. https://doi.org/10.1080/15548627.2025.2610451

 

S.M. Choy, K.Y. Goh, W.X. Lee, W. Jiang, Q. Gou, P.D. Gopal Krishnan, S. Chee Ong, K. Chua, N. Harmston, & H. Tang, Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging, Proc. Natl. Acad. Sci. U.S.A. 122 (48) e2508893122, (2025). https://doi.org/10.1073/pnas.2508893122

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Tzou F.Y, Hong C.L, Chen K.H, Vaughen J.P, Lin W.S, Hsu C.H, Rivas-Serna I.M, Hsu K.Y, Ho S.M, Panganiban M.R, Hsieh H.T, Li Y.J, Hsiao Y, Yeh H.C, Yu C.Y, Tang H.W, Chou Y.H, Wu C.L, Lo C.C, Mazurak V.C, Clandinin M.T, Huang S.Y, Chan C.C. Functional profiling and visualization of the sphingolipid metabolic network in vivo. EMBO Rep 26, 6380–6417 (2025). https://doi.org/10.1038/s44319-025-00632-0

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Priya D. Gopal Krishnan, Wen Xing Lee, Kah Yong Goh, Sze Mun Choy, Lewin Raymarc Roldan Turqueza, Zhuo Han Lim, Hong-Wen Tang; Transcriptional regulation of autophagy in skeletal muscle stem cells. Dis Model Mech 1 February 2025; 18 (2): DMM052007. doi: https://doi.org/10.1242/dmm.052007

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2024

 

Goh, K. Y., Lee, W. X., Choy, S. M., Priyadarshini, G. K., Chua, K., Tan, Q. H., … Tang, H. W. FOXO-regulated DEAF1 controls muscle regeneration through autophagy. Autophagy. July 4, 2024. 10.1080/15548627.2024.2374693

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Lin R.Z, Im G.B, Luo A.C, Zhu Y, Hong X, Neumeyer J, Tang H.W, Perrimon N, Melero-Martin J.M. Mitochondrial transfer mediates endothelial cell engraftment through mitophagy. Nature 629, 660–668 (2024). https://doi.org/10.1038/s41586-024-07340-0

 

2023

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Wang W, Tan J, Liu X, Guo W, Li M, Liu X, Liu Y, Dai W, Hu L, Wang Y, Lu Q, Lee W.X, Tang H.W, Zhou Q. Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress. Nat Commun 14, 6201 (2023). https://doi.org/10.1038/s41467-023-41757-x

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Hong-Wen Tang, ....Norbert Perrimon, Stephanie E. Mohr. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Nature Communications 14: 2162 , April 15, 2023. 10.1038/s41467-023-37876-0

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Chiwei Xu, Jun Xu, Hong-Wen Tang, ..., Norbert Perrimon. A phosphate-sensing organelle regulates phosphate and tissue homeostasis. Nature. May 3, 2023. 10.1038/s41586-023-06039-y

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2022

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Yuanli Wang, Kah Yong Goh, ..., Hong-Wen Tang (Corresponding author). A Novel TP53 Gene Mutation Sustains Non-Small Cell Lung Cancer through Mitophagy. Cells 11(22): 3587, Nov 13, 2022. 10.3390/cells11223587

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Xujun Han, Kah Yong Goh, ..., Hong-Wen Tang (Corresponding author). The Importance of mTORC1-Autophagy Axis for Skeletal Muscle Diseases. International Journal of Molecular Sciences 24(1): 297, Dec 24 2022. 10.3390/ijms24010297

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TDongxia Li, Lizhen Zeng, Yuanli Wang, Hong-Wen Tang, Wen Xing Lee, Zhencheng Chen, Longhui Zhang, Yingchang Zou, Duan Xie, and Fangrong Hu. Terahertz metamaterial biosensor for diagnosis of hepatocellular carcinoma at early stage. Appl. Opt. 61, 4817-4822 (2022). https://opg.optica.org/ao/abstract.cfm?URI=ao-61-16-4817

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2021

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Wenjun Wang, ..., Hong-Wen Tang, Norbert Perrimon, Qinghua Zhou. Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response. Nature Communications 12 (1), 1-15, 2021. 10.1038/s41467-020-20780-2

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Yu-Hsuan Chen,...,Hong-Wen Tang, ..., Ruey-Hwa Chen. VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism. Nature Communications 12, 1322 (2021). 10.1038/s41467-021-21715-1

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Hong-Wen Tang# (Co-corresponding author), ... ,Norbert Perrimon. mTORC1-chaperonin CCT signaling regulates m6A RNA methylation to suppress autophagy. Proceedings of the National. Academy of Sciences. 2021 Mar 9;118(10):e2021945118. 10.1073/pnas.2021945118

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Sungyun Cho, ..., Hong-Wen Tang, ..., Norbert Perrimon, Samie R. Jaffrey, John Blenis. mTORC1 promotes cell growth via m6A-dependent mRNA degradation. Molecular Cell 81, 2064– 2075, May 20, 2021. 10.1016/j.molcel.2021.03.010

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2020

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Chiwei Xu, Brian Franklin, Hong-Wen Tang, ...., and Norbert Perrimon. An in vivo RNAi screen uncovers the role of AdoR signaling and adenosine deaminase in controlling intestinal stem cell activity. Proceedings of the National Academy of Sciences. January 7, 2020 117 (1) 464-471. 10.1073/pnas.1900103117

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Lei Gu,...., Hong-Wen Tang, ...., Norbert Perrimon, Hao Wu, Yang Shi. CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila. Cell Discovery volume 6, Article number: 44 (2020). 10.1038/s41421-020-0178-7

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Anjali Bajpai, Quazi Taushif Ahmad, Hong-Wen Tang, ..., Norbert Perrimon, Pradip Sinha. A Drosophila model of oral peptide therapeutics for adult Intestinal Stem Cell tumors. Disease Models & Mechanisms 2020. 10.1242/dmm.044420

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2019

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Chiwei Xu, Hong-Wen Tang, ...., Norbert Perrimon. The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling. Cell Reports. Jan 2019, 26 (3), 670-688. e6. 10.1016/j.celrep.2018.12.079

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Wei Song, ...., Hong-Wen Tang, ...., Bruce Spiegelman, Norbert Perrimon. Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting via Differential MEK Activation. Developmental Cell. Jan 2019, 48 (2), 277-286. e6. 10.1016/j.devcel.2018.12.003

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2018​

 

Jian Guo, Hong-Wen Tang, Jing Li, Norbert Perrimon, Dong Yan. Xio is a component of the Drosophila sex determination pathway and RNA N6-methyladenosine methyltransferase complex. Proceedings of the National Academy of Sciences. Apr 2018, 115 (14), 3674-3679. 10.1073/pnas.1720945115

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Hong-Wen Tang# (Co-corresponding author), ...., Norbert Perrimon. The TORC1-regulated CPA complex rewires an RNA processing network to drive autophagy and metabolic reprogramming. Cell Metabolism. May 2018, 27 (5), 1040-1054. e8). 10.1016/j.cmet.2018.02.023

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